Genetic Medicine:

Page 11234..1020..»

Cystic Fibrosis: MedlinePlus

Cystic fibrosis (CF) is an inherited disease of the mucus and sweat glands. It affects mostly your lungs, pancreas, liver, intestines, sinuses, and sex organs. CF causes your mucus to be thick and sticky. The mucus clogs the lungs, causing breathing problems and making it easy for bacteria to grow. This can lead to repeated lung infections and lung damage.

The symptoms and severity of CF can vary. Some people have serious problems from birth. Others have a milder version of the disease that doesn’t show up until they are teens or young adults. Sometimes you will have few symptoms, but later you may have more symptoms.

CF is diagnosed through various tests, such as gene, blood, and sweat tests. There is no cure for CF, but treatments have improved greatly in recent years. In the past, most deaths from CF were in children and teenagers. Today, with improved treatments, some people who have CF are living into their forties, fifties, or older. Treatments may include chest physical therapy, nutritional and respiratory therapies, medicines, and exercise.

NIH: National Heart, Lung, and Blood Institute

Originally posted here:
Cystic Fibrosis: MedlinePlus

Read the Rest...

What is Parkinson’s Disease? – Parkinson’s Disease …

Parkinson’s disease (PD) is a chronic and progressive movement disorder, meaning that symptoms continue and worsen over time. Nearly one million people in the US are living with Parkinson’s disease.The cause is unknown, and although there is presently no cure, there are treatment options such as medication and surgery to manage its symptoms.

Parkinsons involves the malfunction and death of vital nerve cells in the brain, called neurons. Parkinson’s primarily affects neurons in an area of the brain called the substantia nigra. Some of these dying neurons produce dopamine, a chemical that sends messages to the part of the brain that controls movement and coordination. As PD progresses, the amount of dopamine produced in the brain decreases, leaving a person unable to control movement normally.

The specific group of symptoms that an individual experiences varies from person to person. Primary motor signs of Parkinsons disease include the following.

Scientists are also exploring the idea that loss of cells in other areas of the brain and body contribute to Parkinsons. For example, researchers have discovered that the hallmark sign of Parkinsons disease clumps of a protein alpha-synuclein, which are also called Lewy Bodies are found not only in the mid-brain but also in the brain stem and the olfactory bulb.

These areas of the brain correlate to nonmotor functions such as sense of smell and sleep regulation. The presence of Lewy bodies in these areas could explain the nonmotor symptoms experienced by some people with PD before any motor sign of the disease appears. The intestines also have dopamine cells that degenerate in Parkinsons, and this may be important in the gastrointestinal symptoms that are part of the disease.

Read the original post:
What is Parkinson’s Disease? – Parkinson’s Disease …

Read the Rest...

Parkinsons Disease Symptoms: Tremors, Stiffness, Weakness …

Symptoms of Parkinson’s disease differ from person to person. They also change as the disease progresses. Symptoms that one person gets in the early stages of the disease, another person may not get until later-or not at all.

Symptoms typically begin appearing between the ages of 50 and 60. They develop slowly and often go unnoticed by family, friends, and even the person who has them.

Michael J. Fox’s Crusade for a Parkinson’s Cure

Michael J. Fox has always been a poster boy. With his youthful good looks and intelligent charm, he rose to fame playing a sassy Republican teenage son of ex-hippie parents in the TV sitcom Family Ties. In the blockbuster Back to the Future film trilogy, he was a time traveler with perfect comedic timing. And in a later sitcom, Spin City, he made us wish all politicians were as personable as his Deputy Mayor Mike Flaherty. In 1998, Fox became a poster boy for another reason: He went public with…

Read the Michael J. Fox’s Crusade for a Parkinson’s Cure article > >

The disease causes motor symptoms and non-motor symptoms. Motor symptoms are those that have to do with how you move. The most common one is tremor.

Tremor, or shaking, often in a hand, arm, or leg, occurs when you’re awake and sitting or standing still (resting tremor), and it gets better when you move that body part.

Tremor is often the first symptom that people with Parkinson’s disease or their family members notice.

At first the tremor may appear in just one arm or leg or only on one side of the body. The tremor also may affect the chin, lips, and tongue.

As the disease progresses, the tremor may spread to both sides of the body. But in some cases the tremor remains on just one side.

Emotional and physical stress tends to make the tremor more noticeable. Sleep, complete relaxation, and intentional movement or action usually reduce or stop the tremor.

Although tremor is one of the most common signs of Parkinson’s, not everyone with tremor has Parkinson’s. Unlike tremor caused by Parkinson’s, tremor caused by other conditions gets better when your arm or hand is not moving and gets worse when you try to move it.

The most common cause of non-Parkinson’s tremor is essential tremor. It’s a treatable condition that is often wrongly diagnosed as Parkinson’s.

Besides tremor, the most common symptoms include:

A small number of people have symptoms on only one side of the body that never move to the other side.

Follow this link:
Parkinsons Disease Symptoms: Tremors, Stiffness, Weakness …

Read the Rest...

Psoriasis –

The precise cause of psoriasis is unknown, but some factors which play a role in the development or progression of psoriasis include: (read more)


Gluten sensitivity

Poor digestion

Bowel toxins

Leaky gut

Liver dysfunction

Heavy alcohol consumption




Certain medications

Family history (genetics)

A bacterial or viral infection may trigger a psoriasis flare up, especially in children. In people with guttate psoriasis, a strep infection usually precedes the onset.Interestingly, certain pathogenic bacteria are found on the skin of psoriasis patients, and when treated with antibiotics, the psoriasis has been shown to subside in most of these patients.

Pathogenic organisms that have been associated with psoriasis include:

Candida albicans

Malassezia ovalis (also found in seborrheic eczema)




Bacillus cereus

Gluten sensitivity may also play a role in the development of psoriasis. A high prevalence of gluten sensitivity has been found in people with psoriasis. In these individuals, a gluten-free diet was found to decrease psoriasis flare ups.Gluten sensitivity has been associated with many other diseases, which illustrates the far-reaching negative effects of a condition that begins in the gut.

Poor digestion or, specifically, poor protein digestion, may contribute to the development of psoriasis. When proteins are not broken down and absorbed properly, they remain in the digestive tract and are, instead, broken down by bacteria in the bowel. The breakdown products, or polyamines, have been found to be increased in psoriasis patients. Psoriasis has also been shown to improve when polyamine levels are decreased.

In addition to polyamine toxins, other gut toxins, such as bacterial toxins and Candida toxins, can influence the rapid regeneration of skin cells that is seen in psoriasis.This is yet one more gut-skin connection. A low-fiber diet contributes to the buildup of these toxins. Fiber binds toxins, and helps move them out of the bowel before they have a chance to cause harm. Toxins can also contribute to gut inflammation, which has been found in people with psoriatic arthritis.

The bowel toxins mentioned above create a toxic environment in the bowel which can create a condition called leaky gut, or increased intestinal permeability. Leaky gut is due to inflammation of the intestinal lining which allows for the passage of larger than normal particles through the intestine. When this occurs, toxins are absorbed into the bloodstream and travel to the liver where they are then detoxified. The toxins are easily absorbed through a leaky gut. Leaky gut has been found to be more prevalent in people with psoriasis than in healthy individuals.If the liver is overburdened, many of these toxins will go directly into the bodys circulation and cause exaggerated immune responses,particularly in genetically susceptible people.

Optimal liver detoxification is increasingly difficult in todays world where chemicals are virtually impossible to avoid. Some naturopathic doctors view psoriasis as the result of the body releasing toxins through the skin because of this overexposure to toxins and the inability of the liver to detoxify them.

It is interesting that heavy alcohol consumption, which imposes a large burden on the liver, is known to be associated with psoriasis.This further illustrates the important role that liver detoxification plays in maintaining health. Similarly, smoking is also linked to psoriasis.This may be due to the increased toxic burden placed on the body by the many chemicals in cigarette smoke.

Stress also contributes to psoriasis. Not only does stress increase itching and worsening of psoriasis,but the psoriasis itself increases stress because of how it affects appearance and ones self-perception. This can create a vicious cycle that makes healing difficult.

Some medications can trigger a psoriasis reaction. Beta blockers, lithium, antimalarial drugs, ACE inhibitors and nonsteroidal anti-inflammatory drugs (NSAIDs) can all activate or worsen psoriasis.

Genetics also plays a role in psoriasis in combination with the environmental factors. About 40 percent of people with psoriasis have a family member with the disorder.

Originally posted here:
Psoriasis –

Read the Rest...

Icahn School of Medicine at Mount Sinai – New York City …

Select Ambulatory Programs Anatomy and Functional Morphology Anesthesiology Anesthesiology, Cardiothoracic Anesthesia Anesthesiology, Pain Management Anesthesiology, Pediatric Anesthesia Biomathematical Sciences Cardiothoracic Surgery Cardiovascular Surgery Center for Comparative Medicine and Surgery Dentistry Dentistry, Oral and Maxillofacial Surgery Dermatology Developmental and Regenerative Biology Emergency Medicine Experimental Therapeutics Institute Family Medicine & Community Health Genetics and Genomic Sciences Geriatrics and Palliative Medicine Geriatrics and Palliative Medicine, Experimental Diabetes and Aging Icahn School of Medicine at Mount Sinai Inpatient Adult Psychiatry Medical Education Medicine Medicine, Cardiology Medicine, Clinical Geriatrics Medicine, Clinical Immunology Medicine, Endocrinology, Diabetes and Bone Disease Medicine, Gastroenterology Medicine, General Internal Medicine Medicine, Hematology and Medical Oncology Medicine, Hospital Medicine Medicine, Infectious Diseases Medicine, Liver Diseases Medicine, Nephrology Medicine, Pulmonary, Critical Care and Sleep Medicine Medicine, Rheumatology Metabolic, Endocrine and Minimally Invasive Surgery Microbiology Mount Sinai Beth Israel Mount Sinai Health System Mount Sinai Roosevelt Mount Sinai St. Luke’s Neurology Neurology, Headache Neurology, Movement Disorders Neurology, Neuromuscular Diseases Neurology, Vestibular/Ocular Neuroscience Neurosurgery Obstetrics, Gynecology and Reproductive Science Oncological Sciences Ophthalmology Orthopaedics Orthopaedics, Foot and Ankle Service Orthopaedics, Spine Division Orthopaedics, Sports Medicine Service Otolaryngology Outpatient Adult Psychiatry Pathology Pathology, Dermatopathology Pediatrics Pediatrics, Adolescent Medicine Pediatrics, Allergy and Immunology Pediatrics, Ambulatory Care Pediatrics, Behavioral Pediatrics Pediatrics, Cardiology Pediatrics, Child Life Pediatrics, Endocrinology – Adrenal Steroid Disorders Pediatrics, Endocrinology and Diabetes Pediatrics, Gastroenterology Pediatrics, General Pediatrics Pediatrics, Hematology/Oncology Pediatrics, Hepatology Pediatrics, Infectious Diseases Pediatrics, Mount Sinai Pediatrics Pediatrics, Nephrology Pediatrics, Neurology Pediatrics, Newborn Medicine Pediatrics, Pediatric Critical Care Medicine Pediatrics, Pediatrics Associates Pediatrics, Pulmonary and Critical Care Pediatrics, Rheumatology Pharmacological Sciences Population Health Science and Policy Preventive Medicine Preventive Medicine, Preventive Medicine Preventive Medicine, Social Work and Behavioral Science Psychiatry Psychiatry, Alcohol and Substance Abuse Psychiatry, Child and Adolescent Psychiatry Psychiatry, Health Services Research Psychiatry, Imaging Psychiatry, Mood and Personality Disorders Psychiatry, Neuropsychology Psychiatry, Schizophrenia Radiation Oncology Radiology Radiology, Oncology Rehabilitation Medicine Surgery Surgery, Colo-Rectal Surgery Surgery, Pediatric Surgery Surgery, Plastic Surgery Surgery, Surgical Oncology Surgery, Vascular Surgery Surgical Intensive Care Unit Thoracic Surgery Urology

See more here:
Icahn School of Medicine at Mount Sinai – New York City …

Read the Rest...

Page 11234..1020..»